Antabuse (Disulfiram) Side Effects

Antabuse side effects, the alcohol-disulfiram reaction, who should avoid it, and safer ways to use disulfiram in alcohol treatment.

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Key takeaway

Antabuse (disulfiram) can cause unpleasant reactions if alcohol is consumed, and it has its own medication side effects and liver cautions. It is not first-line for everyone. Call or text (800) 653-9376 for help comparing alcohol medication options.

Last updated: Wed Oct 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

Antabuse is disulfiram. It works by making drinking alcohol aversive, which is a different strategy than naltrexone or acamprosate.

Call 911 for emergencies. Call or text 988 for a crisis.

Effects without drinking

Drowsiness, headache, taste changes, and skin reactions are among issues people discuss with clinicians. Liver monitoring may be part of safe use.

The alcohol reaction

Drinking while on disulfiram can trigger flushing, nausea, vomiting, and cardiovascular symptoms. This can be dangerous. Read labels on foods and personal-care products for alcohol.

Choosing among AUD medicines

See naltrexone for alcohol and acamprosate side effects. Matching medicine to history beats a one-size sales pitch.

Broker filter

A program that only mentions Antabuse because it sounds strict, without discussing safer-fit alternatives, is not individualized care.

Next step

Clinician review, FindTreatment.gov, or call or text (800) 653-9376.

Additional Resources

Sources cited on this page:

Common Questions

What are Antabuse side effects?

Without alcohol, people may report drowsiness, headache, metallic taste, skin reactions, or other effects. With alcohol, a potentially severe reaction can occur.

What happens if I drink on Antabuse?

Flushing, nausea, vomiting, chest pain, and blood-pressure changes can occur. Severe reactions need emergency care. Avoid alcohol in food, mouthwash, and some products.

Is Antabuse the same as disulfiram?

Antabuse is a brand name for disulfiram. See also disulfiram / Antabuse overview.

Who should avoid it?

Certain heart, liver, and psychiatric histories are cautions. A clinician screens before prescribing.

Are there other alcohol medicines?

Yes. Naltrexone and acamprosate are other FDA-approved options with different risk profiles.