Vivitrol Side Effects

Vivitrol side effects including injection-site pain, nausea, headache, and low mood, plus how the opioid blockade affects pain relief in an emergency.

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Key takeaway

Vivitrol side effects can include injection-site pain, nausea, headache, and low mood. Opioid blockade means pain opioids may not work in an emergency. Call or text (800) 653-9376 to discuss whether injectable naltrexone fits your recovery plan.

Last updated: Wed Oct 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

Vivitrol is extended-release injectable naltrexone used for alcohol and opioid use disorder after opioids are cleared.

Call 911 for emergencies. Call or text 988 for a crisis.

Common reactions

Soreness at the injection site, nausea, and headache happen. Report severe site reactions, yellowing skin, or marked mood changes to the clinic quickly.

Siblings: naltrexone side effects, naltrexone / Vivitrol.

Blockade and emergencies

Tell surgeons and ER staff you are on naltrexone. Wear or carry medical ID when possible.

Broker filter

A monthly shot sold without counseling access or overdose education is incomplete MAT.

Next step

Talk with the prescribing clinic. FindTreatment.gov or call or text (800) 653-9376.

Call or text (800) 653-9376 when Vivitrol side effects or induction timing need plain answers.

Additional Resources

Sources cited on this page:

Common Questions

What are common Vivitrol side effects?

Injection-site reactions, nausea, headache, fatigue, and joint or muscle pain are reported.

Can Vivitrol cause liver problems?

Naltrexone can affect liver labs. Clinicians monitor when risk factors exist.

Why must opioids be cleared first?

Starting naltrexone too soon after opioids can precipitate withdrawal. A washout period is required.

What about emergency pain care?

Carry medical alert information. Opioid pain medicines may not work as usual while blocked.

Is this different from oral naltrexone?

Same active medicine class, different delivery. See naltrexone side effects and naltrexone-vivitrol.