Key takeaway
Lucemyra (lofexidine) is an FDA-approved non-opioid medicine that can ease opioid withdrawal symptoms. It is not a substitute for methadone or buprenorphine for long-term opioid use disorder treatment. Call or text (800) 653-9376 for help comparing withdrawal and MAT options.
Last updated: Wed Oct 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)
Lucemyra is a brand name for lofexidine, a non-opioid medicine used for a short stretch of opioid withdrawal symptom relief. It is not methadone, not buprenorphine, and not a standalone "cure" for opioid use disorder.
Call 911 for emergencies. Call or text 988 for a crisis. For overdose, use naloxone and call 911.
What it does
Lofexidine can reduce some autonomic withdrawal symptoms (sweating, cramps, anxiety-related physical signs) while the body clears opioids. Clinicians usually use it for a limited course with blood-pressure monitoring.
What it does not replace
Long-term risk reduction for opioid use disorder still centers on medications for opioid use disorder such as methadone or buprenorphine when clinically appropriate. Ask how Lucemyra fits with induction or with a plan after the short course ends.
Broker filter
A seller who pitches Lucemyra as enough on its own while blocking buprenorphine or methadone discussion is not following standard opioid care practice.
Next step
Talk with a clinician about withdrawal support and MOUD options, search FindTreatment.gov, or call or text (800) 653-9376.
Additional Resources
Sources cited on this page:
- FDA: Lucemyra (lofexidine) prescribing information
- NIDA: Medications for Opioid Use Disorder
- SAMHSA FindTreatment.gov
- 988 Suicide & Crisis Lifeline
Common Questions
What is Lucemyra?
Lucemyra is the brand name for lofexidine, a non-opioid medicine FDA-approved to reduce opioid withdrawal symptoms for a short course under clinical supervision.
Is Lucemyra the same as Suboxone or methadone?
No. Lucemyra does not activate opioid receptors the way methadone or buprenorphine do. It is used for withdrawal symptom relief, not as long-term MOUD by itself.
What side effects should I know about?
Common effects can include low blood pressure, slow heart rate, dizziness, dry mouth, and sleepiness. Tell the clinician about heart problems and other medicines before starting.
Can I use Lucemyra at home without a plan?
It should be prescribed and monitored. Stopping opioids suddenly still carries relapse and overdose risk once tolerance drops - ask about naloxone and next-step treatment.
Does insurance cover Lucemyra?
Coverage varies by plan and prior authorization. Ask pharmacy benefits and compare with buprenorphine or methadone pathways that treat the underlying disorder.