How to Use Narcan (Naloxone) in an Overdose

Step-by-step Narcan nasal spray use in a suspected opioid overdose, when to call 911, and what to do after the person wakes.

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Key takeaway

Narcan (naloxone) can reverse opioid overdose. Call 911, give naloxone as labeled, start rescue breathing if you know how, and stay until help arrives. A second dose may be needed. Afterward, ask about treatment and take-home naloxone. Call or text (800) 653-9376 for treatment next steps.

Last updated: Wed Oct 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

You need the steps in your hands, not a lecture. Narcan (naloxone) can reverse an opioid overdose. Call 911 first or while you give it. This page is first aid, not a substitute for EMS.

Call or text 988 if you are in crisis after an overdose event.

Steps

Check responsiveness and breathing. If they will not wake and breathing is slow or absent, treat as overdose.
Call 911. Put the phone on speaker if you are alone.
Give naloxone nasal spray as labeled into one nostril. Do not prime the device.
Start rescue breathing or CPR if you are trained and EMS instructions say to.
If no response in 2 to 3 minutes, give another dose in the other nostril per the product instructions.
Stay until help arrives. Naloxone can wear off.

Also read signs of overdose and naloxone and Good Samaritan overdose laws.

After they wake

They may feel sick or want to use again. That urge is withdrawal, not a reason to leave them alone. Ask EMS about hospital evaluation. Offer fentanyl treatment and Suboxone near me conversations when the moment is calmer.

Broker filter

Anyone who uses an overdose as a high-pressure admissions pitch while EMS is still needed is not your ally. Survive first.

Next step

Get take-home naloxone from a pharmacy or health department. For treatment matching, use FindTreatment.gov or call or text (800) 653-9376.

Call or text (800) 653-9376 when you want MOUD options after an overdose scare.

Additional Resources

Sources cited on this page:

Common Questions

How do I give Narcan nasal spray?

Follow the package: peel, place the tip in one nostril, and press the plunger firmly. Do not prime. Give a second dose in the other nostril after 2 to 3 minutes if the person is still not responding, per product instructions and EMS guidance.

Do I still call 911 if I have Narcan?

Yes. Always call 911. Naloxone can wear off. Fentanyl and other opioids may need more than one dose. EMS manages breathing and complications.

Can naloxone hurt someone who did not use opioids?

Naloxone is an opioid antagonist. It is unlikely to harm someone without opioids on board in typical community use, and hesitation kills. If you suspect overdose, give it.

What if they wake up angry or in withdrawal?

Stay calm. Explain you gave naloxone for overdose. Do not let them use again to feel better while you wait for EMS. Offer water if they can swallow safely. Seek medical evaluation.

Where can I get Narcan?

Many pharmacies sell naloxone without an individual prescription under state standing orders. Health departments and harm-reduction programs also distribute it. Ask your pharmacist.